Biological activities of olive oil polyphenols
One of the objectives of the ARISTOIL Transnational Mediterranean Project is to inform consumers about the beneficial properties of a “good” olive oil.
In the issue that you can download from here, an attempt was made by the three Pharmaceutical Schools participating as partners in the ARISTOIL program to record the published studies in valid scientific journals on the actions of the phenols found in olive oil so that the consumer can understand that a “good” olive oil, rich in these phenols, contributes to the health protection of our organism.
Olive oil, if rich in phenols, is a functional food that provides us with protection. Discover the olive oil with the corresponding information. According to Regulation 432/2012 of the European Union, the daily consumption of 20 gr. from olive oil that has at least 5mg tyrosol derivatives and hydroxytyrosol per 20g or 250mg per kg is sufficient to protect against blood lipid oxidation and this olive oil may be called HEALTH CLAIM.
Dr. Nikolaos Krimmnianiotis
Project Coordinator of AristOil Project
Olive oil producer and owner of LIvaGroves SA
INTERREG MED ARISTOIL & ARISTOIL PLUS 2016-2022
Dr KRIMNIANIOTIS NIKOLAOS, PROJECT COORDINATOR
Prof. MAGIATIS PROKOPIOS, SCIENTIFIC OFFICER
POLYPHENOLIC EXTRA VIRGIN OLIVE OIL AND APPLICATIONS DURING PROJECT IMPLEMENTATION
Presentation of Studies
Click HERE for details on the studies.
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Section A: STUDIES APPLICABLE TO HUMANS
Subject: Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic Patients: A Postprandial Study
Place of aplication: Athens
Intervention group: Maria Efthymia Katsa, Kleopatra Ketselidi, Marianna Kalliostra, Anastasios Ioannidis, Andrea Paola Rojas Gil, Panagiotis Diamantakos, Eleni Melliou, Prokopios Magiatis, Tzortzis Nomikos
Research Bodies: University Of Athens(NKUA) Harokopio University
Start-End or ongoing: 2019-2023
Key Conclusions: Positive effect on platelet aggregation in type II diabetic patients
Publication of Conclusions: International Journal of Molecular Sciences, 2024, 25, 2, 908
Subject: Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial
Place of aplication: USA
Intervention group: Amal Kaddoumi,Thomas S. Denney,Gopikrishna Deshpande, Jennifer L. Robinson, Ronald J. Beyers,David T. Redden, Domenico Praticò,Tassos C. Kyriakides, Bonian Lu, Anna N. Kirby, Darren T. Beck and Nancy D. Merner
Research Bodies: Auburn University, USA
Start-End or ongoing: 2021- 2022
Key Conclusions: Positive effect on the cognitive functions of patients with mild mental retardation
Publication of Conclusions: Nutrients, 2022, 14(23), 5102
Subject: The effect of dietary intervention with high-oleocanthal and oleacein olive oil in patients with early-stage chronic lymphocytic leukemia: A pilot randomized trial
Place of aplication: Athens, Sparta
Intervention group: Andrea Paola Rojas Gil, Ioannis Kodonis, Anastasios Ioannidis, Tzortzis Nomikos, Ioannis Dimopoulos, Georgios Kosmidis, Maria Efthymia Katsa, Eleni Melliou, Prokopios Magiatis
Research Bodies: University Of Athens, Harokopio University, University of Peloponnese, Sparta General Hospital
Start-End or ongoing: 2019-2022
Key Conclusions: Positive effect on cancer white blood cells in people with early stage lymphocytic leukemia
Publication of Conclusions: Frontiers in Oncology, 2022, 11, 810249
Subject: Restoration of BMI1 levels after the administration of early harvest extra virgin olive oil as a therapeutic strategy against Alzheimer’s disease
Place of aplication: Thessaloniki
Intervention group: Magda Tsolaki, Eftychia Lazarou, Mahi Kozori, Niki Petridou, Irene Tabakis, Ioulietta Lazarou, Maria Karakota, Iordanis Saoulidis, Eleni Melliou, Prokopios Magiatis
Research Bodies: Aristotle University of Thessaloniki
Start-End or ongoing: 2020-2021
Key Conclusions: Positive effect on the cognitive functions of patients with early stage Alzheimer’s
Publication of Conclusions: Experimental Gerontology, 144, 2021, 111178
Subject: The pleiotropic beneficial intervention of olive oil intake on the Alzheimer’s disease onset via fibrinolytic system
Place of aplication: Thessaloniki
Intervention group: E. Tzekaki, Magda Tsolaki, Αnastasia A. Pantazaki, George Geromichalos, Eftychia Lazarou, Mahi Kozori, Zacharias Sinakos
Research Bodies: Aristotle University of Thessaloniki
Start-End or ongoing: 2020-2021
Key Conclusions: Positive effect on the cognitive functions of patients with early stage Alzheimer’s
Publication of Conclusions: Experimental Gerontology, 150 , 2021, 111344
Subject: The Effect of Cretan High Phenolic Olive Oil on Fecal Calprotectin Levels in the Course of Multiple Sclerosis
Place of aplication: CYPRUS, Thessaloniki
Intervention group: Greta Wozniak, Marios Kyprou and Magda Tsolaki
Research Bodies: Aristotle University of Thessaloniki University of Cyprus
Start-End or ongoing: 2019-2020
Key Conclusions: Positive effect on multiple sclerosis patients
Publication of Conclusions: EC Neurology, 2020, 65-79
Subject: A randomized clinical trial of greek high phenolic early harvest extra virgin olive oil in mild cognitive impairment: The MICOIL pilot study
Place of aplication: Thessaloniki , Athens
Intervention group: Magda Tsolaki, Eftychia Lazarou, Mahi Kozori, Niki Petridou, Irene Tabakis, Ioulietta Lazarou, Maria Karakota, Iordanis Saoulidis, Eleni Melliou, Prokopios Magiatis
Research Bodies: Aristotle University of Thessaloniki, University Of Athens
Start-End or ongoing: 2018-2020
Key Conclusions: Positive effect on the cognitive functions of patients with early stage Alzheimer’s
Publication of Conclusions: Journal of Alzheimer’s Disease, 2020, 78, 2, 801-81
Subject: Assessing validity of self-reported dietary intake within a Mediterranean diet cluster randomized controlled trial among US firefighters
Place of aplication: Athens, USA
Intervention group: Mercedes Sotos-Prieto, Costas Christophi, Alicen Black, Jeremy D Furtado, Yiqing Song, Prokopios Magiatis, Aikaterini Papakonstantinou, Eleni Melliou, Steven Moffatt, Stefanos N Kales
Research Bodies: University Of Athens, Harvard
Start-End or ongoing: 2018-2019
Key Conclusions: Positive effect on various biomarkers measured in firefighters
Publication of Conclusions: Nutrients, 2019, 11, 9, 2250
Subject: Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial
Place of aplication: USA
Intervention group: Karan Agrawal, Eleni Melliou, Xueqi Li, Theresa L Pedersen, Selina C Wang, Prokopios Magiatis, John W Newman, Roberta R Holt
Research Bodies: University Of Athens, UC Davis
Start-End or ongoing: 2016-1017
Key Conclusions: Positive effect on platelet aggregation in healthy people
Publication of Conclusions: Journal of Functional Foods, 2017,36,84-93
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Section B: STUDIES APPLICABLE TO ANIMALS
Subject: Comparison of Oleocanthal-Low EVOO and Oleocanthal against Amyloid-β and Related Pathology in a Mouse Model of Alzheimer’s Disease
Place of aplication: USA
Intervention group: Abdallah, I.M., Al-Shami, K.M., Alkhalifa, A.E., …Guillaume, C., Kaddoumi, A.
Research Bodies: Auburn University, USA
Start-End or ongoing: 2020-2023
Key Conclusions: Positive effect on β-amyloid in an experimental mouse model with Alzheimer’s disease
Publication of Conclusions: Molecules, 2023, 28(3), 1249
Subject: Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer’s Disease
Place of aplication: USA
Intervention group: Yang, E., Wang, J., Woodie, L.N., Greene, M.W., Kaddoumi, A.
Research Bodies: Auburn University, USA
Start-End or ongoing: 2022-2023
Key Conclusions: Positive effect on metabolic and behavioral phenotypes in a mouse model of Alzheimer’s disease
Publication of Conclusions: Molecules, 2023, 28(14), 5592
Subject: A Systematic Ex-Vivo Study of the Anti-Proliferative/Cytotoxic Bioactivity of Major Olive Secoiridoids’ Double Combinations and of Total Olive Oil Phenolic Extracts on Multiple Cell-Culture Based Cancer Models Highlights Synergistic Effects.
Place of aplication: Athens
Intervention group: Aikaterini Papakonstantinou, Petrina Koumarianou, Panagiotis Diamantakos, Eleni Melliou, Prokopios Magiatis, Haralabia Boleti
Research Bodies: University Of Athens, Pasteur Institute
Start-End or ongoing: 2021-2022
Key Conclusions: Positive Effect and Synergistic Effects of Double Combinations of Major Olive Secoiridoids and Total Phenolic Olive Oil Extracts in an Ex-Vivo Study of Anti-Proliferative/Cytotoxic Activity in Cancer Cell Models
Publication of Conclusions: International Journal of Molecular Sciences, 2022, 24,1, 3
Subject: Spontaneous In Vitro and In Vivo Interaction of (−)-Oleocanthal with Glycine in Biological Fluids: Novel Pharmacokinetic Markers
Place of aplication: USA
Intervention group: Lucy I Darakjian, Aimilia Rigakou, Andrew Brannen, Mohammed H Qusa, Niki Tasiakou, Panagiotis Diamantakos, Miranda N Reed, Peter Panizzi, Melissa D Boersma, Eleni Melliou, Khalid A El Sayed, Prokopios Magiatis, Amal Kaddoumi
Research Bodies: University Of Athens, Auburn University, USA
Start-End or ongoing: 2020-2021
Key Conclusions: Finding the chemical structure circulating oleocanthal (as oleoglycine) in biological fluids and how it exerts its positive effect on the brain of mice
Publication of Conclusions: ACS Pharmacology & Translational Science, 2021, 4,1,179-192
Subject: Oleacein attenuates the pathogenesis of experimental autoimmune encephalomyelitis through both antioxidant and anti-inflammatory effects.
Place of aplication: Spain
Intervention group: Beatriz Gutiérrez-Miranda, Isabel Gallardo, Eleni Melliou, Isabel Cabero, Yolanda Álvarez, Prokopios Magiatis, Marita Hernández, María Luisa Nieto
Research Bodies: University Of Athens
Start-End or ongoing: 2019-2020
Key Conclusions: Positive effect in mouse models with autoimmune encephalomyelitis (a model that mimics multiple sclerosis in laboratory animals)
Publication of Conclusions: Antioxidants, 2020, 9, 11, 1161
Subject: Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity
Place of aplication: USA
Intervention group: Siddique, A.B., Ebrahim, H., Mohyeldin, M., Kaddoumi, A., El Sayed, K.
Research Bodies: Auburn University, USA
Start-End or ongoing: 2018-2019
Key Conclusions: Positive effect during oral administration of oleocanthal in mice with breast cancer
Publication of Conclusions: PLoS ONE, 2019, 14(4), 214798
Subject: Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer’s disease
Place of aplication: USA
Intervention group: Yazan S Batarseh, Amal Kaddoumi
Research Bodies: University of Louisiana, USA
Start-End or ongoing: 2017-2018
Key Conclusions: Positive effect and potentiation of Donepezil’s action in reducing β-amyloid and toxicity in a mouse model of Alzheimer’s disease
Publication of Conclusions: The Journal of Nutritional and Biochemistry, 2018, 55, 113-123
Subject: Effect of olive oil phenolics on lipidemic profile and oxidative stress in mice
Place of aplication: Athens
Intervention group: Nikolaos Demertzis, Aikaterini Fotopoulou-Stamatelou, Spyridon Gkinis, Maria Kyriazi, Evangelos Karalis, Georgios Th Papaiwannou, Eleni Melliou, Angeliki Kourounakis, Prokopios Magiatis, Homer S Black, Michail Rallis
Research Bodies: University Of Athens
Start-End or ongoing: 2017-2018
Key Conclusions: Positive effect on lipid profile and oxidative stress in mice
Publication of Conclusions: J Food Nutr Diet, 2018, 2, 114
Click HERE for details on the studies.
